Pure Peptides

Standard peptides are made up of naturally occurring L-amino acids (of which there are twenty) and have a length of 6-25 residues. We offer two purity standards: >80% and >95% by HPLC and can synthesise laboratory-scale amounts from 1mg – gram scale quantities. Turnaround is 2-3 weeks.

Modified peptides include cyclisation, phosphorylation, sulphation, methylation, glycosylation and N/C termini modification.

Extensive capability

Routine peptides - 1 mg - 10 g
Single peptides to large arrays
Cyclic peptides - disulphide and head-to-tail, side-chain-to side or backbone lactam bridged
Post-translational modifications - phosphorylated, sulphated, methylated & glycosylated peptides
C-terminal modifications - secondary amides, alcohols, aldehydes, esters, AMCs, pNAs

Download Peptide Information Sheet

Quality

Purity: >95% by HPLC
Peptide identity confirmed by mass spectrometry (ESI or MALDI-TOF)
In-process control of the synthesis of complex peptides by mass spectrometry and HPLC monitoring

Customer Support

At CRB we pride ourselves on the quality of our antibodies. According to customer feedback:

Detailed consultation on peptide design
Superior building block and synthesis strategies
Custom chemical synthesis of unusual reagents
Regular progress up-dates
Custom aliquotting upon request
Excess peptide retained in stock
Peptide Inventory dating back to 1980

Customer Peptide References

S. E. D. Webb, S. K. Roberts, S. R. Needham, C .J. Tynan, D. R. Rolfe, M. D. Winn, D. T. Clarke, R. Barraclough &
M. L. Martin-Fernandez
Science and Technology Facilities Council and University of Liverpool
Single-Molecule Imaging and Fluorescence Lifetime Imaging Microscopy Show Different Structures for High- and Low-Affinity Epidermal Growth Factor Receptors in A431 Cells
Biophysical Journal 2008, 94: 803-819

X-D. Yang, E. Tajkhorshid & L-F. Chen
University of Illinois
Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κB
Molecular and Cellular Biology 2010, 30: 2170-2180

E. Rajendra & A. R. Venkitaraman
Hutchison/MRC Research Centre, Cambridge
Two Modules in the BRC Repeats of BRCA2 Mediate Structural and Functional Interactions with the RAD51 Recombinase
Nucleic Acids Research 2009, 1-15

PepArray is CRB's multiple peptide synthesis service for the supply of sets of hundreds to thousands of peptides in small amounts for screening purposes.

PepArrays™ are ideal tools for:

T-cell and B-cell epitope mapping
Structure activity studies for receptor binding ligands
Enzyme specificity screening (kinase, protease)
Cytotoxic T-cell assays
Transmembrane loops

Features

48 - 96 peptides/array aliquotted into individual tubes or 96 well plates
3 - 5 μmol scale
Peptides can be made up to 20 residues in length
Quality control: two peptides in each array are sampled for HPLC and MS analysis
Delivery in 2 weeks
Custom aliquotting upon request