Acetyl-Leu-Ala-Thr-Lys-Ala-Ala-(ADMA)-Lys(Me)3-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Ahx-Lys(Biotin)-NH2
Posttranslational modifications of Histones (Acetylation, methylation, phosphorylation) alter their interaction with DNA and act in diverse biological processes such as gene regulation and DNA repair. With the commercial introduction of methylated arginine (mono-, asymmetric di- and symmetric di-) and lysine (mono-, di- and tri-), synthesis of histone peptides has become more straightforward than ever. C-terminal biotinylated H3 (20-40) was synthesised using minimal amounts of asymmetric dimethylarginine and trimethyl lysine.