Technical: Clear %26 informative notes on specialist areas
Modifications
CRB synthesises and supplies a wide range of modified peptides. Some examples are listed below:
N-terminus
- Acetyl, benzoyl, formyl
- Biotin
- Dyes - Alexa, Cy, AttoTec, Chromis, FAM, TAMRA, Dabcyl, Dabsyl, Dansyl
- DOTA & DTPA (metal chelators)
C-terminus
- Amide or acid
- AMC (for fluorogenic substrates)
- EDANS
- Esters (methyl, ethyl etc)
- Hydrazide
- Peptide aldehydes (for protease inhibitors and chemical ligation)
- Peptide hydroxamic acids (for protease inhibitors)
- Substituted amides (methylamides, dimethylamides etc)
- Thiol esters (for chemical ligation)
Unusual amino acids
- D-amino acids
- α-N-methyl amino acids
- ε-N-methylated lysines, NG-methylated arginines
- Phosphoserine, phosphothreonine, phosphorotyrosine
- Sulfotyrosine
- Hydroxyproline
- Amino acid analogues and homologues
- Peptidomimetics
Other modifications
- Intermolecular disulphide bridges
- Lipids (farnesyl, stearoyl etc)
- N-C cyclisation
- PEGylation
- Side-Chain Linked (β-Asp, γ-Glu, ε-Lys)
This is not an exhaustive list and we will be pleased to discuss the synthesis of any modified peptide you require.
