Peptides phosphorylated on the hydroxyl side chains of Tyr, Ser and Thr can be readily synthesised in Fmoc solid phase synthesis using the appropriate side chain protected Fmoc-phospho amino acid. In this way, peptides with a combination of phosphorylated and non-phosphorylated Tyr, Ser and Thr residues can be synthesised.
We specialise in producing highly specific affinity-purified antibodies to phosphorylated peptides and proteins, which do not recognise the non-phosphorylated sequence.