Lantibiotics – surely not more cyclic peptides…

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Figure 3:Use of lanthionine in conventional Fmoc solid phase synthesis of lantibiotics

Cyclic peptides are of increasing interest in drug discovery projects because the cyclic structure allows pharmacophores to be arranged in an optimal conformation for receptor binding and/or because cyclic peptides are resistant to peptidases and hence more stable making them more potent and longer acting.