Getting to the heart of oxidation in health & disease

Posted by & filed under Antibodies, Blog, Post-Translational Modifications, TARGET Antibodies: Polyclonal Antibody Production.

Summary of discussion with Professor Philip Eaton, Professor of Cardiovascular Biochemistry at the Rayne Institute, St Thomas’ Hospital On a mild morning in October, I caught up with Phil at the Rayne Institute, situated within St Thomas’ Hospital, London. Phil’s group works on cardiovascular biochemistry & specifically redox signalling systems. He has been at the Rayne for… Read more »

Cambridge Research Biochemicals Collaborator, Dr. Steven Cobb, University of Durham

Posted by & filed under Blog, Peptide Research, Peptides.

Steven Cobb was introduced to peptide chemistry through working as a post-doc with Professor John Vederas, University of Alberta. After that he moved to the Department of Chemistry in the University of Durham in 2007 and was appointed Lecturer in 2010. The research in the Cobb group is quite wide and varied, covering the whole range of amino-acid, peptide and… Read more »

Antibodies to citrullinated α-enolase peptide 1 are specific for rheumatoid arthritis and cross react with bacterial enolase

Posted by & filed under Antibodies, Blog, Case Studies: Customer's publication, Post-Translational Modifications, TARGET Antibodies: Polyclonal Antibody Production.

Rheumatoid Arthritis (RA) is an autoimmune disease characterised by auto-antibodies generated to antigens that do not under healthy physiological conditions trigger an immune response. The resultant “auto-antigens” trigger and sustain a chronic inflammatory state within the joints of RA patients. The auto-antigens that result in the sustained onset of chronic inflammation in RA are unknown… Read more »

Monocyclic Beta-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

Posted by & filed under Case Studies: Customer's publication, SPECTRUM Peptides: Fluorescent Labelled Peptides.

Monocyclic Beta-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases Chem. Biol. 2011, 6, 325-335 O. Pierrat et al. Rhomboids Discovered a decade ago, Rhomboids are a class of enzymes belonging to the super family of intramembrane proteases which comprises metalloproteases such as site-2 protease (S2P) and aspartyl proteases such as signal peptide peptidase (SPP) and presenilin/g-secretase. They… Read more »

Cambridge Research Biochemicals acquires rights to novel technology useful for development of gene and drug therapies

Posted by & filed under News, Peptides.

Cambridge Research Biochemicals (CRB), a British company specialising in custom supply of research reagents, principally peptides and antibodies for medical research and the Pharmaceutical industry, today announced that it has licensed the rights to a novel and patentable method for parallel assembly of a large number of peptide-therapeutic cargo combinations

Peptide Arrays September 2013

Posted by & filed under Blog, Exhibitions: Peptide meetings, Peptide Research, Peptides, TRANSPORTER Peptides: Peptide Library.

Peptide Arrays After a first edition in London in 2011, ‘Peptide Arrays’ was back this year in Edinburgh. For those who are not totally familiar with this tool, peptide libraries are traditionally un-purified peptides made on a micro-molar scale and either bound to a membrane or provided unbound in a 96-well plate format. They provide an economic… Read more »

8th Chemistry and Biology of Peptides 2013

Posted by & filed under Blog, Exhibitions: Peptide meetings.

This year Nottingham University hosted the 8th Chemistry and Biology of Peptides on the 18th July 2013. The free meeting was organised under the auspices of the Protein & Peptide Science Group (PPSG) of the Royal Society of Chemistry and the European Peptide Society (EPS). With a very friendly atmosphere, the meeting was an opportunity to network,… Read more »