Protein & Peptide Science Group of the Royal Society of Chemistry – not just for academics

Posted by & filed under Blog, Exhibitions: Peptide meetings, Peptide Research.

The Protein & Peptide Science Group (PPSG) of the Royal Society of Chemistry (RSC) is one of the main academic bodies promoting and supporting peptide science research in the UK. It was originally a special interest group of the RSC and called the ‘Peptide & Protein Group’ (proteins obviously weren’t as fashionable in those days) with a focus that… Read more »

The answer is “a cyclic peptide”, now what was the question? An interview with Dr. Ed Tate, Imperial College London

Posted by & filed under Blog, Peptide Research, Peptides, Post-Translational Modifications.

I spoke to Ed Tate recently. Ed was the 2013 winner of the Medimmune Protein & Peptide Science Award and was Plenary speaker at the RSC Protein & Peptide Science Group Early Stage Researcher meeting held in Durham in November 2013 which was sponsored by Cambridge Research Biochemicals.   The Tate group is based in the Department of Chemistry at Imperial College London and their research… Read more »

Custom Antibody Generation to Deubiquitinating Enzyme – OTULIN

Posted by & filed under Antibodies, Case Studies: Customer's publication, TARGET Antibodies: Polyclonal Antibody Production.

Custom Antibody Generation to Deubiquitinating Enzyme – OTULIN Ubiquitination of proteins: Ubiquitination is an important post translational modification (the addition to a protein after it has been synthesized) where ubiquitin is attached to a substrate protein. The addition of ubiquitin to a protein regulates many diverse processes: • Signaling for protein degradation through proteasomes/ lysosomes •… Read more »

Self-Assembling Cages from Coiled-Coil Peptide Modules

Posted by & filed under Blog, Peptalk, Peptide Research, Peptides.

This paper in Science caught my eye earlier in the year. It is another peptide biomaterials paper for which I make no apology – this seems to be a really exciting area of peptide science right now. This is a publication from the laboratory of Prof. Dek Woolfson, University of Bristol, whose work is largely based around α-helical… Read more »

Peptide Biomaterials – the future of peptide science?

Posted by & filed under Blog, Exhibitions: Peptide meetings, News, Peptalk, Peptide Research, Peptides.

Back in the day, peptides were of interest because many hormones were peptides and analogues could be useful for treatment of endocrine disorders and various hormone-dependent cancers. Some, such as Zoladex (Goserelin acetate) even made it into the clinic. Then neuropeptides were (and still are) ‘the next big thing’. Of course, in all of these… Read more »

4th RSC Protein and Peptide Early Researcher Meeting – Collingwood College, University of Durham 11th November 2013

Posted by & filed under Blog, Exhibitions: Peptide meetings, Peptalk, Peptide Research, Peptides, Post-Translational Modifications.

For the first time, the PPSG Early Stage Researcher Meeting (4th year) was held at the University Durham (Collingwood College) rather than London, making it easier for PhD and Post-Doctoral students from the North of England and Scotland to attend and present their research. Professor Alethea Tabor (University College London) was organising the Cambridge Research Biochemicals (CRB) sponsored event with… Read more »

Getting to the heart of oxidation in health & disease

Posted by & filed under Antibodies, Blog, Post-Translational Modifications, TARGET Antibodies: Polyclonal Antibody Production.

Summary of discussion with Professor Philip Eaton, Professor of Cardiovascular Biochemistry at the Rayne Institute, St Thomas’ Hospital On a mild morning in October, I caught up with Phil at the Rayne Institute, situated within St Thomas’ Hospital, London. Phil’s group works on cardiovascular biochemistry & specifically redox signalling systems. He has been at the Rayne for… Read more »

Cambridge Research Biochemicals Collaborator, Dr. Steven Cobb, University of Durham

Posted by & filed under Blog, Peptide Research, Peptides.

Steven Cobb was introduced to peptide chemistry through working as a post-doc with Professor John Vederas, University of Alberta. After that he moved to the Department of Chemistry in the University of Durham in 2007 and was appointed Lecturer in 2010. The research in the Cobb group is quite wide and varied, covering the whole range of amino-acid, peptide and… Read more »

Antibodies to citrullinated α-enolase peptide 1 are specific for rheumatoid arthritis and cross react with bacterial enolase

Posted by & filed under Antibodies, Blog, Case Studies: Customer's publication, Post-Translational Modifications, TARGET Antibodies: Polyclonal Antibody Production.

Rheumatoid Arthritis (RA) is an autoimmune disease characterised by auto-antibodies generated to antigens that do not under healthy physiological conditions trigger an immune response. The resultant “auto-antigens” trigger and sustain a chronic inflammatory state within the joints of RA patients. The auto-antigens that result in the sustained onset of chronic inflammation in RA are unknown… Read more »