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Peptide Nucleic Acids
PNA is a synthetic analogue of DNA in which the ribose phosphate backbone has been replaced by a polyamide chain. PNA can be used in the same applications as conventional DNA/RNA but because of its unique backbone has a number of advantages:
- PNA binds to complementary DNA/RNA with higher affinity and greater specificity than conventional oligonucleotides
- PNA is more stable than DNA or RNA as they are resistant to nucleases and proteases
- PNA can be hydridized at lower salt concentrations than DNA or RNA which leads to higher stringency
These properties make PNA ideal reagents for antisense and antigene applications, and as probes for molecular diagnostics and microarrays.
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Custom PNA Synthesis
CRB offers custom PNAs synthesised with Panagene’s patented BTS technology. This approach allows the routine production of longer PNA oligomers in higher purity than conventional Boc or Fmoc-based methods.
- Scale: 50 nmole to gram
- Length: up to 24 residues routinely. Longer
PNAs are not ususally necessary due to the very high binding affinity of PNA for DNA or RNA.
- Dyes or biotin can be attached to N-terminus,
C-terminus.
- PNA can be supplied conjugated to cell
penetrating peptides to promote cellular uptake.
- Optional Lys or PEG spacers can be
incorporated to increase solubility.
- ISO9001:2000 certified
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PNA Guides
Click to download these PNA guides, you will need Adobe Reader to view these files.
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Need to know more?
Visit the PNA section on our website
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PANArrays™ exploit the excellent stability and specificity of PNA to overcome the limitations of DNA-based arrays.
- Long shelf life
- Reliable SNP detection
- Excellent for long DNA detection
Custom PANArrays™ can be developed for SNP analysis, genotyping, expression profiling, and detection of microrganisms. Using Panagene’s FLASH technology, labelling with a fluorescent dye can be carried out after binding of the DNA to the PNA microarray, saving on the use of expensive
dyes and allowing for more efficient PCR.
For further information see
www.crbdiscovery.com/shop/PANArrays.php
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More PNA-based products
miRNA inhibitors
PNA-based miRNA inhibitors offer numerous advantages over conventional inhibitors:
- Highly sequence specific
- No cytotoxicity
- Resistant to cellular nucleases
CRB offers the complete range of Panagene’s human miRNA inhibitors. Other miRNA inhibitors can be made on request. For further information see www.crbdiscovery.com/shop/miRNA.php
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Globin Reduction PNA
CRB offers PNA probes for reducing RNA in whole blood samples. These probes bind tightly to globin
RNA preventing globin cRNA synthesis, which leads to improved sensitivity against non-globin cRNA. For further information see:
www.crbdiscovery.com/shop/pnaglobinreduction.php
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PNA Telomere FISH probes
PNA Telomere FISH probes are useful tools for determining telomere length. PNA-based FISH probes offer fast hybridization and less background noise than conventional DNA-based probes. For further information see: www.crbdiscovery.com/shop/pnatelomere.php
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View our full range of products
Visit our website to view our full range of products, we offer products for the following:
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