Nucleopeptide

Nucleopeptide

H-Gly-Ala-[Tyr(pU-pU)]-Thr-Gly-Leu-Pro-Asn-Lys-Lys- Pro-Asn-Val-Pro-Thr-IIe-Arg-Thr-Ala-Lys-Val-Gln-OH

Nucleopeptide layout

A diuridylylated VPg (Viral Protein genome-linked) peptide (VPgpUpU) was synthesised by Fmoc SPPS. Mild deprotection of the tyrosine and coupling of the adequately protected phosphoramidate followed by oxidation and deacetylation/desilylation enabled the preparation of the nucleopeptide.

Nucleopeptide graph